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Diabetes mellitus

Biomedical Models of Cellular and Physiological Systems and Disease

Project Leader(s): 

Dr. Daniel Coombs, University of British Columbia

Project Website: 

http://www.math.ubc.ca/~coombs/MITACS/index.htm

Project team: 
Dr. Christopher Cairo, University of Alberta
Dr. Eric Cytrynbaum, University of British Columbia
Dr. Leah Keshet, University of British Columbia
Dr. Michael C. Mackey, McGill University
Dr. Bruce Verchere, Child and Family Institute of BC
Dr. Gerda de Vries, University of Alberta
Non-academic participants: 

Juvenile Diabetes Research Foundation

MERCK

National Science Foundation - Washington University, Department of Physics

StemCell Technologies

Funding period: 
February 25, 2022 - March 31, 2021

Diseases such as diabetes, Alzheimer's, HIV and blood disorders present challenges to our society, our healthcare and our basic scientific understanding of physiological processes within the human body. Mathematical modelling can be used to help scientists decipher the processes at work in these complex diseases at a molecular, cellular and organ level. Recently, research team members examined the ways in which drugs such as Filgrastim could be used to replenish levels of white blood cells, a common challenge following chemotherapy.

Tags: 
health

Statistical Genetic Modelling and Analysis of Complex Traits

Project Leader(s): 

Dr. Shelley Bull, University of Toronto

Project Website: 

http://research.lunenfeld.ca/mprime/DEFAULT.ASP

Project team: 
Dr. Rafal Kustra, University of Toronto
Dr. David Tritchler, University of Toronto
Dr. Gerarda Darlington, University of Guelph
Dr. Celia Greenwood, University of Toronto
Dr. Kenneth Morgan, McGill University
Dr. Jinko Graham, Simon Fraser University
Dr. Brad McNeney, Simon Fraser University
Dr. J.C. Loredo-Osti, Memorial University of Newfoundland
Dr. Joseph Beyene, University of Toronto
Non-academic participants: 
Funding period: 
February 25, 2022 - March 31, 2021

Complex traits, such as susceptibility to diabetes, cancer or tuberculosis, which vary in human and natural populations, are determined by multiple genetic and environmental factors that interact with one another in complicated ways. This interaction depends upon population characteristics as well as characteristics of the individual and the family.

Tags: 
health