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Molecular biology

Improving Genome Annotation, Molecular Structure and Interaction Prediction: An Algorithmic Study of Biomolecular Functions

Project Leader(s): 

Dr. Anne Condon , University of British Columbia

Project Website: 

http://www.cs.ubc.ca/labs/beta/mitacs/index.htm

Project team: 
Dr. Holger H. Hoos, University of British Columbia
Dr. Ming Li, University of Waterloo
Dr. Irmtraud Meyer, University of British Columbia
Dr. S. Cenk Sahinalp, Simon Fraser University
Dr. Ladislav Stacho, Simon Fraser University
Dr. Peter J. Unrau, Simon Fraser University
Dr. Kaizhong Zhang, University of Western Ontario
Non-academic participants: 

BC Genome Sciences Centre
BC Cancer Researh Centre
IBM Canada
MED BIOGENE Inc
Michael Smith Foundation for Health Research
Zymeworks Inc

Funding period: 
April 1, 2021 - March 31, 2021
Tags: 
health

Assembly and Analysis of 2-base Encoded Sequencing Data

Project Leader(s): 

Dr. Michael Brudno, University of Toronto

Project Website: 

http://compbio.cs.toronto.edu/dibase/

Project team: 
Dr. Quaid Morris, University of Toronto
Dr. Asher Cutter, University of Toronto
Dr. Alan Moses, University of Toronto
Dr. Lucian Ilie, University of Western Ontario
Non-academic participants: 

Applied Biosystems

Hospital for Sick Children (Sick Kids)

Funding period: 
1 April 2021 - 31 March 2021

Even as the number of sequenced genomes is growing rapidly, the process of assembling sequencing data into a genome remains exceptionally challenging. The difficulty is due to the fact that current technologies are unable to sequence a whole genome in one pass, relying instead on the shotgun method: the genome is broken into many small segments (reads) whose sequence is then determined. The information about the location of these reads in the genome is lost, and the assembler must put them back together using the information about the overlaps between the reads.

Tags: 
health