University of Ottawa

Coherent Anti-Stokes Raman Scattering (CARS) microscopy is a very promising method of directly imaging biological processes occurring in living cells. It is unique because the imaging does not harm the cell, is molecule specific, and does not require the introduction of additional chemicals that may alter the biology. For example, CARS would allow us to visualize how viruses invade a cell membrane, which is still a mystery.

The goal of the MITACS-funded research program on reverse-engineering cellular complexity is to develop new mathematical tools and algorithms for analyzing genetic switching networks. Many genes operate as switches and are turned on and off, like light bulbs, when needed. Understanding the regulatory circuits that control this switching behaviour would improve our ability to modulate gene activity, provide clues to fundamental biological design principles, and lead to better synthetic circuits for biotechnological applications.